Should I make parts of my manuscript in different fonts?

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Whenever you can, use standard type face. Usually do not italicize words, place them in bold, simulate handwriting, or send a children’s piece in child-like font.

Make your submissions as easy to read as possible. If something is usually to be in a different font, underline it instead of putting it into that font in the manuscript. Never put full words and phrases in capital letters, unless the publication recommends it.